Granulocyte Colony-Stimulating Factor

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Accepting patients

Total Marrow and Lymphoid Irradiation

Phase II Study of Evaluating the Efficacy of Total Marrow and Lymphoid Irradiation (TMLI) as the Conditioning Regimen for HLA-Haploidentical Hematopoietic Cell Transplantation in Patients With Myelodysplasia or Acute Leukemia
  • Allogeneic Stem Cell Transplant
  • Phase 2

Accepting patients

211At-BC8-B10

A Phase I/II Study Evaluating Escalating Doses of 211At-Labeled Anti-CD45 MAb BC8-B10 (211At-BC8-B10) Followed by Related Haplo-Identical Allogeneic Hematopoietic Cell Transplantation for High-Risk Acute Leukemia or Myelodysplastic Syndrome (MDS)
  • Allogeneic Stem Cell Transplant
  • Monoclonal Antibody
  • Phase 1/2

Accepting patients

T Cell Receptor Depletion in Stem Cell Transplant

Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders
  • Monoclonal Antibody
  • T Cell (Allogeneic)
  • CD20
  • Phase 2

Accepting patients

RAFA

A Phase II Trial of HSCT for the Treatment of Patients With Fanconi Anemia Lacking a Genotypically Identical Donor, Using a Risk-Adjusted Chemotherapy Only Cytoreduction With Busulfan, Cyclophosphamide and Fludarabine
  • Allogeneic Stem Cell Transplant
  • Phase 2

Accepting patients

PVEK (IMGN632)

Phase 1 Study of FLAG-Ida With Pivekimab Sunirine (PVEK [IMGN632]) for Adults With Newly Diagnosed Adverse-Risk Acute Myeloid Leukemia and Other High-Grade Myeloid Neoplasms
  • Antibody Drug Conjugate (ADC)
  • CD123
  • Phase 1

Accepting patients

Combination Chemotherapy Pre-Allogeneic SCT

Pilot Study of FLAG-Ida Followed Immediately by Reduced-Intensity Allogeneic HCT for Adults Age 60 and Older With Newly Diagnosed Adverse-Risk AML or Other High-Grade Myeloid Neoplasm
  • Allogeneic Stem Cell Transplant
  • Chemotherapy
  • Radiation
  • Phase 2

Accepting patients

CMV-MVA Triplex Vaccination

Placebo-Controlled and Randomized Phase 2 Trial of CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors to Enhance CMV-Specific Immunity and Prevent CMV Viremia in Recipients After Hematopoietic Stem Cell Transplant
  • Allogeneic Stem Cell Transplant
  • Vaccine
  • Placebo
  • Randomization
  • Phase 2