T Cell Receptor Depletion in Stem Cell Transplant

Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders

What's the purpose of the trial?

This is a phase II trial of T cell receptor alpha/beta depletion (α/β TCD) hematopoietic cell transplantation (HCT) transplantation in patients with Fanconi anemia (FA) to eliminate the need for routine graft-versus-host disease (GVHD) immune suppression leading to earlier immune recovery and potentially a reduction in the risk of severe infections after transplantation.
Trial status

Accepting patients

Phase
Phase 2
Enrollment
48
Last Updated
1 month ago
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Participating Centers

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Experimental Treatments

Learn more about the experimental treatments being evaluated in this clinical trial.

  • Busulfan is a chemotherapy cancer medication that interferes with the growth and spread of cancer cells in the body, and may be used in the treatment of many different cancers.
  • Cyclophosphamide is a chemotherapy agent used in the treatment of cancer.
  • Fludarabine is a chemotherapy medication that may be used in the treatment of many different cancers.
  • Granulocyte Colony-Stimulating Factor is a glycoprotein used to stimulate the bone marrow to help with granulocyte and stem cell production.
  • Methylprednisolone is a corticosteroid that prevents the release of substances in the body that cause inflammation, and is given in conjunction with some cancer treatments.
  • Rituximab is an anti-CD20 monoclonal antibody currently approved for use in B-Cell Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukemia, and several autoimmune conditions.
  • Total Body Irradiation is radiation therapy that is given to your entire body.

Arms / Cohorts

Explore eligibility, treatments and learn more about potential cohorts.

Accepting patients

Plan 1

Accepting patients

Plan 2

Accepting patients

Plan 3

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