211At-BC8-B10
A Phase I/II Study Evaluating Escalating Doses of 211At-Labeled Anti-CD45 MAb BC8-B10 (211At-BC8-B10) Followed by Related Haplo-Identical Allogeneic Hematopoietic Cell Transplantation for High-Risk Acute Leukemia or Myelodysplastic Syndrome (MDS)
What's the purpose of the trial?
This phase I/II trial studies the side effects and best dose of a radioactive agent linked to an antibody (211At-BC8-B10) followed by donor stem cell transplant in treating patients with high-risk acute leukemia or myelodysplastic syndrome that has come back (recurrent) or isn't responding to treatment (refractory).
Not currently accepting
For Healthcare Professionals Only
This site is intended for healthcare professionals in the US. Patients and care partners can explore and connect with MDS clinical trials through our patient portal.
Participating Centers
There is one center participating in this trial. Enter a location below to view the distance.
Experimental Treatments
Learn more about the experimental treatments being evaluated in this clinical trial.
- Allogeneic Stem Cell Transplant is a type of stem cell transplant that utilizes a donor's pre-collected stem cells to rescue the bone marrow from the toxic effects of very high dose chemotherapy.
- Astatine At 211 Anti-CD45 Monoclonal Antibody BC8-B10 Astatine At 211 Anti-CD45 Monoclonal Antibody BC8-B10 is a monoclonal antibody that is designed to deliver cytotoxic radiation to cancer cells. It is being studied for use in several different indications.
- Cyclophosphamide is a chemotherapy agent used in the treatment of cancer.
- Fludarabine is a chemotherapy medication that may be used in the treatment of many different cancers.
- Granulocyte Colony-Stimulating Factor is a glycoprotein used to stimulate the bone marrow to help with granulocyte and stem cell production.
- Mycophenolate Mofetil is an immunosuppressive medication used to help prevent rejection in patients who have had a transplant.
- Tacrolimus is an immunosuppressive medication used to help prevent rejection in patients who have had a transplant.
- Total Body Irradiation is radiation therapy that is given to your entire body.
Arms / Cohorts
Explore eligibility, treatments and learn more about potential cohorts.
Not currently accepting
Real People. Real Support.
Need help connecting with this clinical trial? We're here to help!
Print a patient-friendly report to share with your patient.
We can help answer any questions and connect you (or your patient) with the study team.
Schedule a time that is convenient and we’ll call you to see how we can help you and your patient.