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Olutasidenib Combination Therapy
A Phase 2 Study Evaluating Olutasidenib in Combination With Hypomethylating Agents in Patients With IDH1-mutated Higher-risk Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Advanced Myeloproliferative Neoplasm
Learn more- IDH1 Inhibitor
- Phase 2
Accepting patients
Cirtuvivint
A Phase I Study Evaluating the Safety of Cirtuvivint as Monotherapy and in Combination With ASTX727 and ASTX727 + Venetoclax in Patients With Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)
Learn more- CLK Inhibitor
- Phase 1
Accepting patients
A Phase I/II Study of Venetoclax in Combination With ASTX727 (Cedazuridine/Decitabine) in Treatment-Naïve High-Risk Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML)
Learn more- BCL-2 Inhibitor
- Hypomethylating Agents (HMA)
- Phase 1/2
- Has results
Accepting patients
Pembrolizumab, Decitabine +/- Venetoclax
Phase 1b Study of Pembrolizumab, Decitabine +/- Venetoclax Combination Therapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
Learn more- BCL-2 Inhibitor
- Hypomethylating Agents (HMA)
- Monoclonal Antibody
- Phase 1
Accepting patients
Azacitidine and Decitabine
Proof-Of-Concept Study of Metabolically Optimized, Non-Cytotoxic 5-Azacitidine and Decitabine Epigenetic Therapy for Myeloid Malignancies
Learn more- Hypomethylating Agents (HMA)
- Phase 1
Accepting patients
Cytarabine Alternating with Decitabine
Phase II Study of Cladribine Plus Low Dose Cytarabine (LDAC) Induction Followed By Consolidation With Cladribine Plus LDAC Alternating With Decitabine in Patients With Untreated Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS)
Learn more- Hypomethylating Agents (HMA)
- Phase 2
Accepting patients
Quizartinib with Decitabine and Venetoclax
A Phase I/II Study of Quizartinib in Combination With Decitabine and Venetoclax for the Treatment of Patients With Acute Myeloid Leukemia (AML)
Learn more- BCL-2 Inhibitor
- Hypomethylating Agents (HMA)
- Tyrosine Kinase (TK) Inhibitor
- Phase 1/2
- Has results
Accepting patients
Gemtuzumab as Part of Chemotherapy
A Phase 2 Study of Fludarabine, Cytarabine, Filgrastim-sndz,Gemtuzumab Ozogamicin and Idarubicin in Newly Diagnosed Core Binding Factor Associated Acute Myelogenous Leukemia
Learn more- Antibody Drug Conjugate (ADC)
- Hypomethylating Agents (HMA)
- White Blood Cell Stimulant
- CD33
- Phase 2
Accepting patients
TWT-202
Phase 1b/2 Clinical Study of the Safety, Tolerability, and Pharmacokinetic and Pharmacodynamic Profiles of CFI-400945 as a Single Agent or in Combination With Azacitidine or Decitabine in Patients With AML, MDS or CMML
Learn more- Hypomethylating Agents (HMA)
- PLK4 Inhibitor
- Phase 1/2
- Has results
Accepting patients
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A Pilot Study to Evaluate the Feasibility of Post-Hematopoietic Stem Cell Transplant Prophylaxis With Decitabine Combined With Filgrastim for Children and Young Adults With AML, MDS and Related Myeloid Malignancies
Learn more- Hypomethylating Agents (HMA)
- White Blood Cell Stimulant
- Maintenance
- Phase 2