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Olutasidenib Combination Therapy

A Phase 2 Study Evaluating Olutasidenib in Combination With Hypomethylating Agents in Patients With IDH1-mutated Higher-risk Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Advanced Myeloproliferative Neoplasm
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  • IDH1 Inhibitor
  • Phase 2

Accepting patients

Cirtuvivint

A Phase I Study Evaluating the Safety of Cirtuvivint as Monotherapy and in Combination With ASTX727 and ASTX727 + Venetoclax in Patients With Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)
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  • CLK Inhibitor
  • Phase 1

Accepting patients

A Phase I/II Study of Venetoclax in Combination With ASTX727 (Cedazuridine/Decitabine) in Treatment-Naïve High-Risk Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML)
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  • BCL-2 Inhibitor
  • Hypomethylating Agents (HMA)
  • Phase 1/2
  • Has results

Accepting patients

Pembrolizumab, Decitabine +/- Venetoclax

Phase 1b Study of Pembrolizumab, Decitabine +/- Venetoclax Combination Therapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
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  • BCL-2 Inhibitor
  • Hypomethylating Agents (HMA)
  • Monoclonal Antibody
  • Phase 1

Accepting patients

Azacitidine and Decitabine

Proof-Of-Concept Study of Metabolically Optimized, Non-Cytotoxic 5-Azacitidine and Decitabine Epigenetic Therapy for Myeloid Malignancies
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  • Hypomethylating Agents (HMA)
  • Phase 1

Accepting patients

Cytarabine Alternating with Decitabine

Phase II Study of Cladribine Plus Low Dose Cytarabine (LDAC) Induction Followed By Consolidation With Cladribine Plus LDAC Alternating With Decitabine in Patients With Untreated Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS)
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  • Hypomethylating Agents (HMA)
  • Phase 2

Accepting patients

Quizartinib with Decitabine and Venetoclax

A Phase I/II Study of Quizartinib in Combination With Decitabine and Venetoclax for the Treatment of Patients With Acute Myeloid Leukemia (AML)
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  • BCL-2 Inhibitor
  • Hypomethylating Agents (HMA)
  • Tyrosine Kinase (TK) Inhibitor
  • Phase 1/2
  • Has results

Accepting patients

Gemtuzumab as Part of Chemotherapy

A Phase 2 Study of Fludarabine, Cytarabine, Filgrastim-sndz,Gemtuzumab Ozogamicin and Idarubicin in Newly Diagnosed Core Binding Factor Associated Acute Myelogenous Leukemia
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  • Antibody Drug Conjugate (ADC)
  • Hypomethylating Agents (HMA)
  • White Blood Cell Stimulant
  • CD33
  • Phase 2

Accepting patients

TWT-202

Phase 1b/2 Clinical Study of the Safety, Tolerability, and Pharmacokinetic and Pharmacodynamic Profiles of CFI-400945 as a Single Agent or in Combination With Azacitidine or Decitabine in Patients With AML, MDS or CMML
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  • Hypomethylating Agents (HMA)
  • PLK4 Inhibitor
  • Phase 1/2
  • Has results

Accepting patients

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A Pilot Study to Evaluate the Feasibility of Post-Hematopoietic Stem Cell Transplant Prophylaxis With Decitabine Combined With Filgrastim for Children and Young Adults With AML, MDS and Related Myeloid Malignancies
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  • Hypomethylating Agents (HMA)
  • White Blood Cell Stimulant
  • Maintenance
  • Phase 2