Busulfan

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Accepting patients

ACCESS

HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide (ACCESS)
  • Allogeneic Stem Cell Transplant
  • Pre-Transplant
  • Phase 2

Accepting patients

OPTIMIZE

A Phase II Study of Reduced Dose Post Transplantation Cyclophosphamide as GvHD Prophylaxis in Adult Patients With Hematologic Malignancies Receiving HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation
  • Allogeneic Stem Cell Transplant
  • Phase 2

Accepting patients

Cord Blood Transplantation in Children

Cord Blood Transplantation in Children and Young Adults With Hematologic Malignancies and Non-malignant Disorders
  • Allogeneic Stem Cell Transplant
  • Phase 2

Accepting patients

Donor Lymphocyte Infusion Post Transplant

Phase I/II Study Using Prophylactic Donor Lymphocyte Infusion Early Post-Transplant After Allogeneic Hematopoietic Cell Transplantation Using Post-Transplantation Cyclophosphamide for High-Risk Hematologic Malignancies
  • Donor Lymphocyte Infusion (DLI)
  • Post-Allogeneic Stem Cell Transplant
  • Phase 1/2

Not currently accepting

CD34+ Enriched Transplant

A Phase II Trial of CD34+ Enriched Transplants From HLA-Compatible Related or Unrelated Donors for Treatment of Patients With Myelodysplastic Syndrome
  • Allogeneic Stem Cell Transplant
  • CD34
  • Phase 2

Accepting patients

Graft Versus Host Disease-Reduction Strategies

A Phase II Randomized Controlled Trial Comparing GVHD-Reduction Strategies for Allogeneic Peripheral Blood Transplantation (PBSCT) for Patients With Acute Leukemia or Myelodysplastic Syndrome: Selective Depletion of CD45RA+ Naïve T Cells (TND) vs. Post-Transplantation Cyclophosphamide (PTCy)
  • Allogeneic Stem Cell Transplant
  • Phase 2

Accepting patients

Venetoclax as Part of Pre-Transplant Chemotherapy

Venetoclax to Improve Outcomes of Fractionated Busulfan Regimen in Patients With High-Risk AML and MDS
  • BCL-2 Inhibitor
  • Phase 2

Accepting patients

T Cell Receptor Depletion in Stem Cell Transplant

Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders
  • Monoclonal Antibody
  • T Cell (Allogeneic)
  • CD20
  • Phase 2

Accepting patients

Venetoclax in Pre- and Post-Transplant Therapy

A Phase 1 Study of Adding Venetoclax to a Reduced Intensity Conditioning Regimen and to Maintenance in Combination With a Hypomethylating Agent After Allogeneic Hematopoietic Cell Transplantation for Patients With High Risk AML, MDS, and MDS/MPN Overlap Syndromes
  • Allogeneic Stem Cell Transplant
  • Antimetabolites
  • BCL-2 Inhibitor
  • Chemotherapy
  • Hypomethylating Agents (HMA)
  • Phase 1

Accepting patients

RAFA

A Phase II Trial of HSCT for the Treatment of Patients With Fanconi Anemia Lacking a Genotypically Identical Donor, Using a Risk-Adjusted Chemotherapy Only Cytoreduction With Busulfan, Cyclophosphamide and Fludarabine
  • Allogeneic Stem Cell Transplant
  • Phase 2