Phase I Study of Escalating Doses of 225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody Added to the Conditioning Regimen of Fludarabine, Melphalan and Organ Sparing Total Marrow and Lymphoid Irradiation (TMLI) as Conditioning for Allogeneic Hematopoietic Cell Transplantation in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome
What's the purpose of the trial?
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Participating Centers
There is one center participating in this trial. Enter a location below to view the distance.
Experimental Treatments
Learn more about the experimental treatments being evaluated in this clinical trial.
- Allogeneic Stem Cell Transplant is a type of stem cell transplant that utilizes a donor's pre-collected stem cells to rescue the bone marrow from the toxic effects of very high dose chemotherapy.
- Fludarabine is a chemotherapy medication that may be used in the treatment of many different cancers.
- Melphalan is a chemotherapy medication used in the treatment of different cancers.
- Radiation therapy uses high doses of radiation to help target and kill many different kinds of cancer throughout the body.
- Sirolimus is an immunosuppressive medication used in several indications, including to help prevent rejection in patients who have had a transplant.
- Tacrolimus is an immunosuppressive medication used to help prevent rejection in patients who have had a transplant.
Arms / Cohorts
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Accepting patients
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