Antithymocyte Globulin (ATG)

Atgam

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Accepting patients

Horse Anti-Thymocyte Globulin (hATG)

Phase II Study of Horse Anti-Thymocyte Globulin (hATG), Cyclosporine, Methylprednisolone, and GCSF (Filgrastim or Pegfilgrastim) in Patients With Aplastic Anemia (AA), or Low/Int-1 Risk Myelodysplastic Syndrome (MDS)
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  • White Blood Cell Stimulant
  • Steroid
  • Phase 2

Accepting patients

RAFA

A Phase II Trial of HSCT for the Treatment of Patients With Fanconi Anemia Lacking a Genotypically Identical Donor, Using a Risk-Adjusted Chemotherapy Only Cytoreduction With Busulfan, Cyclophosphamide and Fludarabine
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  • Allogeneic Stem Cell Transplant
  • Phase 2

Accepting patients

Mismatched Related vs. Matched Unrelated Donor

A Multi-Center, Phase 3, Randomized Trial of Matched Unrelated Donor (MUD) Versus HLA-Haploidentical Related (Haplo) Myeloablative Hematopoietic Cell Transplantation for Children, Adolescents, and Young Adults (AYA) With Acute Leukemia or Myelodysplastic Syndrome (MDS)
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  • Allogeneic Stem Cell Transplant
  • Monoclonal Antibody
  • Phase 3

Not yet accepting

2 Step ATG

Phase II Clinical Trial of 2 Step ATG Combined With Tacrolimus and Mini Methotrexate for Prevention of Acute GVHD Post Myeloablative Allogeneic Stem Cell Transplant
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  • Phase 2

Accepting patients

Allogeneic Stem Cell Transplant

MT2023-20: Hematopoietic Cell Transplant With Reduced Intensity Conditioning and Post-transplant Cyclophosphamide for Severe Aplastic Anemia and Other Forms of Acquired Bone Marrow Failure.
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  • Allogeneic Stem Cell Transplant
  • Phase 2

Accepting patients

ATG Plus Cyclophosphamide To Prevent GVHD

A Randomized Pilot Trial Comparing Anti-Thymocyte Globulin (ATG) With ATG Plus Post Transplant Cyclophosphamide (PTCy) for Prophylaxis Against Acute and Chronic Graft Versus Host Disease (GVHD)
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  • Allogeneic Stem Cell Transplant
  • Randomization
  • Phase 2

Accepting patients

Personalized Natural Killer Cell Therapy

Personalized NK Cell Therapy After Chemotherapy and Cord Blood Transplant in Treating Patients With Myelodysplastic Syndrome, Leukemia, Lymphoma or Multiple Myeloma
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  • Natural Killer Cells (Allogeneic)
  • Phase 2

Accepting patients

Cytokine-Treated Veto Cells Post-Transplant

Cytokine-Treated Veto Cells in Treating Participants With Hematologic Malignancies Following Stem Cell Transplant
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  • Allogeneic Stem Cell Transplant
  • Phase 1/2

Accepting patients

AB-CliniMACs

Unrelated And Partially Matched Related Donor Peripheral Stem Cell Transplantation With Alpha/Beta T Cell And B Cell Depletion For Patients With Hematologic Malignancies
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  • Allogeneic Stem Cell Transplant
  • T Cell
  • Phase 2

Not yet accepting

ATG Dosing for GVHD Prevention

Phase II Clinical Trial of 2 Step ATG Combined With Tacrolimus and Mini Methotrexate for Prevention of Acute GVHD Post Reduced Intensity Allogeneic Stem Cell Transplant
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  • Phase 2