Cytokine-Treated Veto Cells Post-Transplant
Cytokine-Treated Veto Cells in Treating Participants With Hematologic Malignancies Following Stem Cell Transplant
What's the purpose of the trial?
This phase I/II trial studies how well cytokine-treated veto cells work in treating participants with hematologic malignancies following stem cell transplant. Giving chemotherapy and total-body irradiation before a stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. When the healthy stem cells from a donor are infused into the participant, they may help the participant's bone marrow make stem cells, red blood cells, white blood cells, and platelets. cytokine-treated veto cells may help the transplanted donor cells to develop and grow in recipients without causing graft-versus-host-disease (GVHD - when transplanted donor tissue attacks the tissues of the recipient's body).
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Participating Centers
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Experimental Treatments
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- Allogeneic Stem Cell Transplant is a type of stem cell transplant that utilizes a donor's pre-collected stem cells to rescue the bone marrow from the toxic effects of very high dose chemotherapy.
- Antithymocyte Globulin (ATG) is an antibody preparation made from rabbits or horses immune cells altered with human thymocytes. ATG is used to prevent or treat acute cellular rejection after solid organ transplantation and as a therapy for certain other blood disorders.
- Cyclophosphamide is a chemotherapy agent used in the treatment of cancer.
- Cytokine-treated Veto Cells are a type of white blood cell that helps to monitor the immune system. Researchers are testing cytokine-treated veto cells to see if they may help donor cells (after a transplant) to develop and grow in recipients without causing graft-versus-host-disease.
- Fludarabine is a chemotherapy medication that may be used in the treatment of many different cancers.
- Total Body Irradiation is radiation therapy that is given to your entire body.
Arms / Cohorts
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