Ruxolitinib

Jakafi

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Accepting patients

Phase 1 Trial for Patients With Advanced Hematologic Malignancies Undergoing Reduced Intensity Allogeneic HCT With a T-cell Depleted Graft With Infusion of Conventional T-cells and Regulatory T-cells
  • Allogeneic Stem Cell Transplant
  • Phase 1

Accepting patients

Evaluation of Ruxolitinib and Azacytidine Combination as a Therapy for Patients With Myelofibrosis and Myelodysplastic Syndrome/ Myeloproliferative Neoplasm
  • JAK1 Inhibitor
  • Kinase Inhibitor
  • Tyrosine Kinase (TK) Inhibitor
  • Phase 2
  • Has results

Accepting patients

Decitabine Plus a JAK-Inhibitor

A Phase 2 Trial Investigating Decitabine in Combination With a JAK-Inhibitor as a Bridge to Allogeneic Hematopoietic Stem Cell Transplant in Patients With Accelerated/Blast Phase Myeloproliferative Neoplasms
  • Hypomethylating Agents (HMA)
  • JAK1 Inhibitor
  • JAK2 Inhibitor
  • Phase 2

Accepting patients

LIMBER

A Phase 1, Open-Label, Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasms
  • BET Inhibitor
  • JAK1 Inhibitor
  • JAK2 Inhibitor
  • Phase 1

Accepting patients

Ruxolitinib for GVHD Prevention

Phase 2a Study of Adding Ruxolitinib With Tacrolimus/Methotrexate Regimen for Graft-versus-Host Disease Prophylaxis in Myeloablative Conditioning Hematopoietic Cell Transplantation in Pediatric and Young Adult Patients
  • Allogeneic Stem Cell Transplant
  • JAK1 Inhibitor
  • JAK2 Inhibitor
  • Tyrosine Kinase (TK) Inhibitor
  • Phase 2

Not yet accepting

Orca-T

Phase I Trial for Patients With Advanced Hematologic Malignancies Undergoing Allogeneic Hematopoietic Cell Transplantation From an HLA-Mismatched Donor (7/8) With Orca-T
  • Allogeneic Stem Cell Transplant
  • T Cell (Allogeneic)
  • Phase 1