Alvin J. Siteman Cancer Center

Washington University Medical Campus

St. Louis, MO

Accepting patients

Atorvastatin vs. Rosuvastatin

Pilot Study of Statins in Patients With Clonal Cytopenia of Undetermined Significance (CCUS) and Myelodysplastic Syndromes (MDS)
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  • Statin
  • Phase 2

Accepting patients

DEC-C Post-Transplant

A Phase I/II Trial of Pre-emptive Therapy With DEC-C to Improve Outcomes in MDS Patients With Measurable Residual Disease Post Allogeneic Hematopoietic Cell Transplant
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  • Cytidine Deaminase Inhibitor
  • Phase 1/2

Accepting patients

ChromoSeq

A Prospective Study of Whole Genome Sequencing (ChromoSeq) as an Adjunct to Conventional Genomic Profiling in MDS
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  • Genetic Sequencing
  • Laboratory Assay
  • Observational Trial

Accepting patients

Identification of Drug Sensitization

Identification of AML/MDS Drug Sensitization by in Vivo Chemotherapy Administration
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Accepting patients

ChromoSeq

A Prospective Study of Whole Genome Sequencing (ChromoSeq) as an Adjunct to Conventional Genomic Profiling in AML and MDS
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  • Laboratory Assay
  • Observational Trial

Accepting patients

AZD6738

A Phase Ib Study of AZD6738 for Patients With Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia Progressing on Front-Line Therapy
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  • Kinase Inhibitor
  • Phase 1

Accepting patients

NC525

A Phase 1, Open-Label, Safety, Tolerability, And Efficacy Study of NC525 in Subjects With Advanced Myeloid Neoplasms
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  • Monoclonal Antibody
  • Phase 1

Accepting patients

CC-91633 (BMS-986397)

A Phase 1, Open-label, Dose-finding Study of CC-91633 (BMS-986397) in Subjects With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher-Risk Myelodysplastic Syndromes
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  • CELMoD
  • Phase 1

Accepting patients

Mismatched Related vs. Matched Unrelated Donor

A Multi-Center, Phase 3, Randomized Trial of Matched Unrelated Donor (MUD) Versus HLA-Haploidentical Related (Haplo) Myeloablative Hematopoietic Cell Transplantation for Children, Adolescents, and Young Adults (AYA) With Acute Leukemia or Myelodysplastic Syndrome (MDS)
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  • Allogeneic Stem Cell Transplant
  • Monoclonal Antibody
  • Phase 3

Accepting patients

Maintenance Ruxolitinib

Phase II Study of Maintenance Ruxolitinib After Allogeneic Stem Cell Transplantation for Older Patients With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) in Complete Remission
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  • JAK2 Inhibitor
  • Tyrosine Kinase (TK) Inhibitor
  • Maintenance
  • Phase 2