AK117/Placebo with Azacitidine

A Randomized, Double-blind, Placebo-controlled, Multicenter Phase 2 Study of AK117/Placebo in Combination With Azacitidine in Patients With Newly Diagnosed Higher-risk Myelodysplastic Syndromes

What's the purpose of the trial?

This is a Phase 2 randomized, double-blind, placebo-controlled, multicenter study evaluating the efficacy and safety of AK117 or placebo, combined with azacitidine in patients with newly diagnosed higher-risk myelodysplastic syndromes (HR-MDS).
Trial status

Accepting patients

Phase
Phase 2
Enrollment
90
Last Updated
1 month ago
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Participating Centers

There are 12 centers participating in this trial. Enter a location below to find the closest center.

Experimental Treatments

Learn more about the experimental treatments being evaluated in this clinical trial.

  • AK117 is a kind of drug called a monoclonal antibody that targets the CD47 protein which is highly expressed by some cancers.
  • Azacitidine is a type of chemotherapy called a hypomethylating agent that interferes with the growth and spread of cancer cells in the body. 
  • Placebo is a substance that has no therapeutic effect and can be used as a control in testing new drugs in clinical trials.

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