Cleveland Clinic - Taussig Cancer Center

Taussig Cancer Institute

Cleveland, OH

Sorting 12 by

Not yet accepting

ELRiSE MDS

A Phase 3, Multicenter, Open-Label, Randomized Trial to Compare the Efficacy and Safety of Elritercept Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes in ESA-naïve Adult Participants Who Require Red Blood Cell Transfusions
  • Activin Receptor IIA Inhibitor
  • Randomization
  • Phase 3

Accepting patients

RENEW

A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions
  • Activin Receptor IIA Inhibitor
  • Placebo
  • Closed Label (Masked)
  • Phase 3

Accepting patients

RALLY-MF

RALLY-MF: A Phase 1b/2 Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of DISC-0974 in Participants with Myelofibrosis or Myelodysplastic Syndrome and AnemiaA Phase 1b/2a Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DISC-0974 in Participants with Myelofibrosis and Anemia
  • Monoclonal Antibody
  • Hemojuvelin (HJV)
  • Randomization
  • Monotherapy
  • Phase 1/2
  • Has results

Accepting patients

IRAK

Phase 1b Study of R289 in Patients with Lower-risk Myelodysplastic Syndromes (LR MDS)
  • IRAK 1 Inhibitor
  • IRAK 4 Inhibitor
  • Phase 1/2
  • Has results

Not yet accepting

Naïve T Cell Depletion

Multi-Center Phase II Randomized Controlled Trial of Naïve T Cell Depletion for Prevention of Chronic Graft-Versus-Host Disease in Children and Young Adults
  • Allogeneic Stem Cell Transplant
  • Pre-Allogeneic Stem Cell Transplant
  • Phase 2

Accepting patients

Eltrombopag

Eltrombopag as a Novel Therapeutic Approach for Low-risk MDS and CMML With TET2 Mutations
  • White Blood Cell Stimulant
  • Thrombopoietin Receptor Agonist (TPO-RA)
  • Phase 2

Not yet accepting

Olutasidenib Maintenance

Pilot Trial of Olutasidenib Maintenance Post Allogeneic Hematopoietic Cell Transplantation in Patients Carrying IDH1 Mutation With AML, MDS, or CMML Disease
  • IDH1 Inhibitor
  • Phase 1

Accepting patients

Safety Study of Cord Blood Units

Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation
  • Allogeneic Stem Cell Transplant
  • Phase 2

Not currently accepting

Luspatercept and Lenalidomide (L2)

A Multicenter, Phase Ib/II Study That Combines Luspatercept and Lenalidomide (L2) in Lower-risk, Non-del(5q) MDS Patients
  • Red Blood Cell Stimulant
  • Erythroid Maturation Agent (EMA)
  • Immunomodulatory Drug
  • Phase 1/2

Accepting patients

Eganelisib

A Phase 1b Open-Label Study to Evaluate the Safety and Tolerability of Eganelisib as Monotherapy and in Combination With Cytarabine in Patients With Relapsed/Refractory Acute Myeloid Leukemia
  • PI3K Inhibitor
  • Randomization
  • Phase 1