ELRiSE MDS

A Phase 3, Multicenter, Open-Label, Randomized Trial to Compare the Efficacy and Safety of Elritercept Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes in ESA-naïve Adult Participants Who Require Red Blood Cell Transfusions

What's the purpose of the trial?

The main aim of this study is to assess how elritercept works in lowering the need for RBC (red blood cell) transfusions and how safe elritercept is when compared with epoetin alfa. Other aims are to learn if elritercept improves tiredness as reported by participants without needing RBC transfusion compared with epoetin alfa, the RBC transfusion burden and quality of life compared with epoetin alfa. The study also aims to find out the extent of the immune response to elritercept. The study will also check on the medical problems (safety) of elritercept.
Trial status

Accepting patients

Phase
Phase 3
Enrollment
300
Last Updated

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Participating Centers

There are 28 centers participating in this trial. Enter a location below to find the closest center.

Experimental Treatments

Learn more about the experimental treatments being evaluated in this clinical trial.

  • Epoetin Alfa is a bone marrow stimulant medication used to treat anemia in several different indications. 
  • Elritercept is an investigational bone marrow stimulating medication being studied for use in myelodysplastic syndrome (MDS).

Arms / Cohorts

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Accepting patients

Epoetin Alfa

Accepting patients

Elritercept

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