ACCELERATE

A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

What's the purpose of the trial?

The purpose of this clinical trial is to compare drug combinations to learn which drugs work best to prevent graft-versus-host-disease (GVHD) in people who have received a stem cell transplant. The source of stem cells is from someone who is not related and has a different blood cell type than the study participant. The researchers will compare the new drug combination to a standard drug combination. They will also learn about the safety of each drug combination. Participants will: * Receive the standard or new drug combination after transplant * Visit the doctor's office for check-ups and tests after transplant that are routine for most transplant patients * Take surveys about physical and emotional well-being * Give blood and stool samples.
Trial status

Accepting patients

Phase
Phase 2
Enrollment
358
Last Updated

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Participating Centers

There are 16 centers participating in this trial. Enter a location below to find the closest center.

Experimental Treatments

Learn more about the experimental treatments being evaluated in this clinical trial.

  • Tacrolimus is an immunosuppressive medication used to help prevent rejection in patients who have had a transplant.
  • Mycophenolate Mofetil is an immunosuppressive medication used to help prevent rejection in patients who have had a transplant.
  • Abatacept is a kind of a drug called a selective costimulation modulator, which blocks the activity of T cells to treat symptoms of inflammatory conditions in the body. 
  • Ruxolitinib is a tyrosine kinase inhibitor in development for the treatment of several different blood cancers.

Arms / Cohorts

Explore eligibility, treatments and learn more about potential cohorts.

Accepting patients

Control/SOC

Accepting patients

ACCEL-001

Accepting patients

ACCEL-002

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