Tagraxofusp for Post-Transplant Maintenance

Phase I Study of Tagraxofusp for Post-Transplant Maintenance for Patients With CD 123+ Acute Myeloid Leukemia, Myelodysplastic Syndrome, Myelofibrosis and Chronic Myelomonocytic Leukemia

What's the purpose of the trial?

In this study, tagraxofusp (Tag) is given to patients with CD 123+ myelofibrosis (MF), chronic myelomonocytic leukemia (CMML), and acute myeloid leukemia (AML) after allogeneic stem cell transplant (HCT) to help prevent relapse. Patients will receive up to about 9 cycles of treatment with Tag and have a bone marrow biopsy after cycle 4 and about 1 year after HCT.
Trial status

Accepting patients

Phase
Phase 1
Enrollment
44
Last Updated
1 month ago

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Experimental Treatments

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  • Tagraxofusp is a first-in-class CD123 fusion protein that is approved for treatment in Blastic Plasmacytoid Dendritic Cell Neoplasm. 

Arms / Cohorts

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Accepting patients

Tagraxofusp (escalating doses)

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