Abatacept in Double Cord Blood Unit Transplant

ABBA CORD: Double Umbilical Cord Blood Transplants With Abatacept for Graft Versus Host Disease Prophylaxis

What's the purpose of the trial?

The goal of this clinical trial is to see if adding abatacept to tacrolimus and MMF prevents or reduces the chances of acute graft versus host disease which is a complication that can occur after transplant in participants with blood cancer. The usual therapy for graft versus host disease prevention after a cord blood transplant includes tacrolimus and MMF. The main question this clinical trial aims to answer is whether or not abatacept will be safe and effective in reducing aGVHD rates in dCBT. Participants will: * Partake in exams, tests, and procedures as part of usual cancer care. * Partake in conditioning, which is the treatment that is given before a transplant. * Have a cord blood transplant. * Partake in radiation following the transplant.
Trial status

Not yet accepting

Phase
Phase 2
Enrollment
20
Last Updated

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Participating Centers

There is one center participating in this trial. Enter a location below to view the distance.

Experimental Treatments

Learn more about the experimental treatments being evaluated in this clinical trial.

  • Abatacept is a kind of a drug called a selective costimulation modulator, which blocks the activity of T cells to treat symptoms of inflammatory conditions in the body. 
  • Tacrolimus is an immunosuppressive medication used to help prevent rejection in patients who have had a transplant.
  • Fludarabine is a chemotherapy medication that may be used in the treatment of many different cancers.
  • Umbilical cord blood unit (CBU) is the blood that remains in the umbilical cord and placenta after childbirth. Umbilical cord blood contains stem cells, and can be used to treat some hematological conditions.
  • Cyclophosphamide is a chemotherapy agent used in the treatment of cancer.
  • Mycophenolate Mofetil is an immunosuppressive medication used to help prevent rejection in patients who have had a transplant.
  • Thiotepa is an antineoplastic chemotherapy agent that is used to treat several different kinds of cancer.

Arms / Cohorts

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Not yet accepting

Cy/Flu/Thio/TBI + dCBT + Tac/MMF + Abatacept

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