DFV890

A Phase 1b, Open Label, Multi-center, Dose Optimization and Dose Expansion Study to Assess the Safety and Efficacy of DFV890 in Adult Patients With Myeloid Diseases

What's the purpose of the trial?

Study CDFV890G12101 is an open-label, phase 1b, multicenter study with a randomized two-dose optimization part, and a dose expansion part consisting of two groups evaluating DFV890 in patients with myeloid diseases. The purpose of this study is to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, efficacy and recommended dose for single agent DFV890 in patients with lower risk (LR: very low, low or intermediate risk) myelodysplastic syndromes (LR MDS) and lower risk chronic myelomonocytic leukemia (LR CMML).

Trial status

Accepting patients

Phase

Phase 1

Enrollment

Last Updated

1 month ago

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Participating Centers

There are 16 centers participating in this trial. Enter a location below to find the closest center.

Experimental Treatments

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DFV890 is an oral NLRP3 inhibitor being studied for use in several different indications.

Arms / Cohorts

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Accepting patients

DFV890 low dose

Accepting patients

DFV890 high dose

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