Hyperbaric Oxygen Therapy

A Pilot Study to Determine the Safety and Efficacy of Incorporating Hyperbaric Oxygen Therapy Into RIC Fludarabine and Melphalan and Allogeneic Hematopoietic Stem/Progenitor Transplantation

What's the purpose of the trial?

The purpose of this study is to determine if hyperbaric oxygen therapy is safe in the setting of stem cell transplantation. This study will also determine if hyperbaric oxygen therapy improves engraftment, graft versus host disease, neutrophil count, and incidence and severity of mucositis (inflammation of the mouth or gut) and infection. This study has two cohorts. The first cohort is subjects with acute myeloid leukemia (AML) or Myelodysplastic Syndrome (MDS). The second cohort is subjects with chronic myelomonocytic leukemia (CMML), atypical chronic myeloid leukemia (aCML), chronic monocytic leukemia, chronic neutrophilic leukemia (CNL), myelofibrosis, and myelodysplastic/myeloproliferative (MDS/MPN) overlap syndrome. The first cohort has completed the recruitment so only the second cohort will be recruited.

Trial status

Accepting patients

Phase

Phase 1

Enrollment

Last Updated

1 month ago

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Experimental Treatments

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Allogeneic Stem Cell Transplant is a type of stem cell transplant that utilizes a donor's pre-collected stem cells to rescue the bone marrow from the toxic effects of very high dose chemotherapy.
Hyperbaric Oxygen therapy involves breathing in pure oxygen in a pressurized environment to help with a variety of different conditions. It is being studied to see if it improves response to stem cell transplants in cancer patients.

Arms / Cohorts

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Accepting patients

AML or MDS

Accepting patients

Cohort 2- CMML, aCML, CML, CNL, MDS/MPN

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