Vorinostat Post-Transplant

Epigenetic Modification for Relapse Prevention: a Dose-finding Study of Vorinostat Used in Combination With Low-dose Azacitidine in Children Undergoing Allogeneic Hematopoietic Cell Transplantation for Myeloid Malignancies

What's the purpose of the trial?

The objective of this study is to evaluate the maximum tolerated (MTD) of vorinostat used in combination with low-dose azacitidine after allogeneic hematopoietic cell transplantation (alloHCT) for prevention of relapse of childhood myeloid malignancies.
Trial status

Accepting patients

Phase
Phase 1
Enrollment
15
Last Updated
2 months ago
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Participating Centers

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Experimental Treatments

Learn more about the experimental treatments being evaluated in this clinical trial.

  • Azacitidine is a type of chemotherapy called a hypomethylating agent that interferes with the growth and spread of cancer cells in the body. 
  • Vorinostat is an HDAC inhibitor that is FDA approved for use in treating cutaneous T cell lymphoma (CTCL). It is being studied for use in several other indications.

Arms / Cohorts

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Accepting patients

Vorinostat + Azacitidine

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