Heart Protection w/Dexrazoxane During Chemotherapy

Cardioprotection With Dexrazoxane in Acute Myeloid Leukemia (AML), High-Risk Myelodysplastic Syndrome (MDS), Myeloid Blast Phase of Chronic Myeloid Leukemia (CML), Ph+ AML, and Myeloid Blast Phase of Myeloproliferative Neoplasms

What's the purpose of the trial?

This phase II trial studies how well dexrazoxane hydrochloride works in preventing heart-related side effects of chemotherapy in participants with blood cancers, such as acute myeloid leukemia, myelodysplastic syndrome, chronic myeloid leukemia, and myeloproliferative neoplasms. Chemoprotective drugs, such as dexrazoxane hydrochloride, may protect the heart from the side effects of drugs used in chemotherapy, such as cladribine, idarubicin, cytarabine, and gemtuzumab ozogamicin, in participants with blood cancers.
Trial status

Accepting patients

Phase
Phase 2
Enrollment
100
Last Updated
1 month ago
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Experimental Treatments

Learn more about the experimental treatments being evaluated in this clinical trial.

  • Cladribine is a chemotherapy medication approved for use in hairy cell leukemia, B-cell chronic lymphocytic leukemia, and multiple sclerosis. 
  • Cytarabine is an antineoplastic chemotherapy agent that is FDA approved to treat several different kinds of leukemia.
  • Dexrazoxane Hydrochloride is a cardioprotective agent that is given alongside some chemotherapies to help protect from side effects.
  • Gemtuzumab Ozogamicin is an antibody drug conjugate that is approved for use in acute myeloid leukemia, and being studied for use in other indications.
  • Idarubicin is an anti-neoplastic chemotherapy drug used to treat several different kinds of cancers.

Arms / Cohorts

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Accepting patients

Dexrazoxane hydrochloride + Chemotherapy

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