Cord Blood-derived NK Cells

Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances

What's the purpose of the trial?

The goal of this clinical research study is to learn about the safety of giving immune cells called natural killer (NK) cells with chemotherapy to patients with leukemia, lymphoma, or multiple myeloma. Immune system cells (such as NK cells) are made by the body to attack foreign or cancerous cells. Researchers think that NK cells you receive from a donor may react against cancer cells in your body, which may help to control the disease.
Trial status

Accepting patients

Phase
Phase 1/2
Enrollment
94
Last Updated
1 month ago
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Participating Centers

There is one center participating in this trial. Enter a location below to view the distance.

Experimental Treatments

Learn more about the experimental treatments being evaluated in this clinical trial.

  • Cyclophosphamide is a chemotherapy agent used in the treatment of cancer.
  • Fludarabine is a chemotherapy medication that may be used in the treatment of many different cancers.
  • Natural Killer (NK) Cells (Allogeneic) are cells already found in the body that are being modified and tested in cancer patients to try to help reduce transplant cell production time and reduce graft versus host disease. 

Arms / Cohorts

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Accepting patients

Cyclophosphamide

Accepting patients

CAR.70/IL15-transduced CB-NK cells

Accepting patients

Fludarabine phosphate

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