CPX-351 Plus Ivosidenib

Phase II Investigator Sponsored Study of CPX-351 in Combination With Ivosidenib for Patients With IDH1 Mutated Acute Myeloid Leukemia or High-Risk MDS

What's the purpose of the trial?

This phase II trial investigates how well CPX-351 and ivosidenib work in treating patients with acute myeloid leukemia or high-risk myelodysplastic syndrome that has IDH1 mutation. The safety of this drug combination will also be studied. IDH1 is a type of genetic mutation (change). Chemotherapy drugs, such as CPX-351, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Ivosidenib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. The purpose of this trial is to learn if CPX-351 in combination with ivosidenib can help to control IDH1-mutated acute myeloid leukemia or high-risk myelodysplastic syndrome.
Trial status

Accepting patients

Phase
Phase 2
Enrollment
30
Last Updated
1 month ago
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Experimental Treatments

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  • CPX-351 is a drug that combines cytarabine and daunorubicin, and is approved for the treatment of acute myeloma leukemia. It is currently being studied for use in several other cancers.
  • Ivosidenib is a small molecule inhibitor that is approved for use in acute myeloid leukemia and cholangiocarcinoma.

Arms / Cohorts

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Accepting patients

CPX-351 + Ivosidenib

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