CPX-351

Phase 1 Dose Escalation Study of CPX-351 for Patients With Int-2 or High Risk IPSS Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia After Failure to Hypomethylating Agents

What's the purpose of the trial?

This phase I trial studies best dose and side effects of liposome-encapsulated daunorubicin-cytarabine (CPX-351) and how well it works in treating patients with high risk myelodysplastic syndrome or chronic myelomonocytic leukemia that has come back or has not responded to treatment. Drugs used in chemotherapy, such as liposome-encapsulated daunorubicin-cytarabine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Trial status

Accepting patients

Phase
Phase 1
Enrollment
38
Last Updated
1 month ago
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Experimental Treatments

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  • CPX-351 is a drug that combines cytarabine and daunorubicin, and is approved for the treatment of acute myeloma leukemia. It is currently being studied for use in several other cancers.

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Accepting patients

CPX-351

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