APG-115

A Phase Ib/II Study of APG-115 Alone or in Combination With Azacitidine in Patients With Relapse/Refractory AML, CMML or MDS

What's the purpose of the trial?

This is a two Part study in patients with relapsed/refractory acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML), or high risk myelodysplastic syndrome (MDS) that will initially evaluate the safety and tolerability of APG-115 as a single agent in Part 1, followed by a combination of APG-115 + 5-azacitidine (5-AZA) in Part 2.
Trial status

Accepting patients

Phase
Phase 1/2
Enrollment
69
Last Updated
4 weeks ago
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Participating Centers

There are 8 centers participating in this trial. Enter a location below to find the closest center.

Experimental Treatments

Learn more about the experimental treatments being evaluated in this clinical trial.

  • APG-115 is kind of drug called a small-molecule MDM2 inhibitor that may work by helping the immune system fight cancer and cause cancer cells to die.
  • Azacitidine is a type of chemotherapy called a hypomethylating agent that interferes with the growth and spread of cancer cells in the body. 

Arms / Cohorts

Explore eligibility, treatments and learn more about potential cohorts.

Accepting patients

APG-115

Accepting patients

APG-115 + Azacitidine

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