Inqovi

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Accepting patients

Decitabine/Cedazuridine as Maintenance Therapy

A Phase Ib Study of Oral Decitabine/Cedazuridine as Maintenance Therapy Following Allogeneic Hematopoietic Cell Transplantation for Patients With Myeloid Neoplasms
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  • Cytidine Deaminase Inhibitor
  • Hypomethylating Agents (HMA)
  • Phase 1

Accepting patients

DEC-C Post-Transplant

A Phase I/II Trial of Pre-emptive Therapy With DEC-C to Improve Outcomes in MDS Patients With Measurable Residual Disease Post Allogeneic Hematopoietic Cell Transplant
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  • Cytidine Deaminase Inhibitor
  • Phase 1/2

Accepting patients

Eltanexor Plus Inqovi

A Phase I/II Trial of Eltanexor (KPT-8602) With Inqovi (Decitabine-Cedazuridine) in High-Risk Myelodysplastic Syndromes
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  • Nucleoside Metabolic Inhibitor
  • SINE
  • Phase 1/2

Accepting patients

Venetoclax in Combination With ASTX727

Venetoclax in Combination With ASTX727, an All-ORal Therapy for Chronic Myelomonocytic Leukemia and Other MDS/MPN With Excess Blasts (VICTORY-MDS/MPN): A Randomized, Phase 2 Trial
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  • BCL-2 Inhibitor
  • Hypomethylating Agents (HMA)
  • Phase 2

Accepting patients

Venetoclax in Pre- and Post-Transplant Therapy

A Phase 1 Study of Adding Venetoclax to a Reduced Intensity Conditioning Regimen and to Maintenance in Combination With a Hypomethylating Agent After Allogeneic Hematopoietic Cell Transplantation for Patients With High Risk AML, MDS, and MDS/MPN Overlap Syndromes
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  • Allogeneic Stem Cell Transplant
  • Antimetabolites
  • BCL-2 Inhibitor
  • Chemotherapy
  • Hypomethylating Agents (HMA)
  • Phase 1

Accepting patients

ASTX727, Venetoclax, and Gilteritinib

A Phase I/II Study of ASTX727, Venetoclax, and Gilteritinib for Patients With Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome With an Activating FLT3 Mutation
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  • BCL-2 Inhibitor
  • Cytidine Deaminase Inhibitor
  • Nucleoside Metabolic Inhibitor
  • Tyrosine Kinase (TK) Inhibitor
  • Phase 1/2

Accepting patients

ABNL-MARRO

The ABNL-MARRO 001 Study: A Phase 1/2 Study of Active Myeloid Target Compound Combinations in MDS/MPN Overlap Syndromes.
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  • Chemotherapy
  • Phase 1/2
  • Has results