City of Hope Comprehensive Cancer Center
Beckman Research Institute
Duarte, CA
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- Monoclonal Antibody
- Phase 1
Not yet accepting
NEXI-001
Phase 1b Expansion Study of Multi-Antigen Specific CD8+ T Cells After Decitabine-enhanced Lymphodepletion: an Adoptive Cellular Therapy for Patients with Relapsed or Refractory AML or MDS Following an Allogeneic Hematopoietic Cell Transplantation from Matched HLA Donors
Learn more- Allogeneic Stem Cell Transplant
- T Cell (Allogeneic)
- Post-Allogeneic Stem Cell Transplant
- Phase 1
Accepting patients
ACCESS
HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide (ACCESS)
Learn more- Allogeneic Stem Cell Transplant
- Pre-Transplant
- Phase 2
Not currently accepting
A Phase 1/2, Open Label, Multicenter Study to Investigate the Safety and Efficacy of Fadraciclib (CYC065), an Oral CDK 2/9 Inhibitor, in Subjects With Leukemias or Myelodysplastic Syndrome (MDS)
Learn more- Cyclin-Dependent Kinase Inhibitor (CDK Inhibitor)
- Phase 1/2
Accepting patients
Total Marrow and Lymphoid Irradiation
Phase II Study of Evaluating the Efficacy of Total Marrow and Lymphoid Irradiation (TMLI) as the Conditioning Regimen for HLA-Haploidentical Hematopoietic Cell Transplantation in Patients With Myelodysplasia or Acute Leukemia
Learn more- Allogeneic Stem Cell Transplant
- Phase 2
Accepting patients
Basiliximab
Phase I Study of Escalating Doses of 90Y-DOTA-Anti-CD25 Monoclonal Antibody Added to the Conditioning Regimen of Fludarabine, Melphalan, and Organ Sparing Total Marrow and Lymphoid Irradiation (TMLI) as Conditioning for Allogeneic Hematopoietic Cell Transplantation in Patients With High-Risk Acute Leukemia or Myelodysplastic Syndrome
Learn more- Chemotherapy
- Monoclonal Antibody
- CD25
- Radiation
- Phase 1
Accepting patients
Pembrolizumab, Decitabine +/- Venetoclax
Phase 1b Study of Pembrolizumab, Decitabine +/- Venetoclax Combination Therapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
Learn more- BCL-2 Inhibitor
- Hypomethylating Agents (HMA)
- Monoclonal Antibody
- Phase 1
Accepting patients
BTX-A51
A First-In-Human, Open-Label, Escalating Multiple-Dose Study to Evaluate the Safety, Toxicity, and Pharmacokinetics of BTX-A51 Capsules Alone and in Combination With Azacitidine in Patients With Relapsed or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome
Learn more- CK1-Alpha Inhibitor
- Phase 1
- Has results
Accepting patients
Total Marrow and Lymphoid Irradiation
Phase I Study of Escalating Doses of Total Marrow and Lymphoid Irradiation (TMLI) Combined With Fludarabine and Melphalan as Conditioning for Allogeneic Hematopoietic Cell Transplantation in Patients With High-Risk Acute Leukemia or Myelodysplastic Syndrome
Learn more- Chemotherapy
- Radiation
- Phase 1
Accepting patients
SL-401
Phase 1 Study of SL-401 in Combination With Azacitidine and Venetoclax in Relapsed/Refractory Acute Myeloid Leukemia (AML) and in Treatment-Naive Subjects With AML Not Eligible for Standard Induction and in Subjects With Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) or SL-401 in Combination With Azacitidine in Subjects With High-Risk Myelodysplastic Syndrome (MDS)
Learn more- BCL-2 Inhibitor
- Hypomethylating Agents (HMA)
- Phase 1